Toward personalized dose-prescription in locally advanced non-small cell lung cancer: Validation of published normal tissue complication probability models
نویسندگان
چکیده
منابع مشابه
Multimodality treatment in locally advanced non-small cell lung cancer.
Prognosis in patients with locally advanced non-small cell lung cancer (NSCLC) is poor (five year survival rate of 5% [1]). Radiotherapy (RT), chemotherapy (CT) and surgery (S), as single modality therapeutical approaches are unable to eradicate locoregional disease and to control systemic microscopic disease. Concurrent chemoradiation (CTRT) is at present time deemed to be the standard of care...
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OBJECTIVE The objective of this study was to evaluate the role of neoadjuvant chemotherapy in the treatment of locally advanced non small cell lung cancer (NSCLC) followed by radiotherapy versus radiotherapy alone. MATERIAL AND METHODS Sixty nine patients were randomized to chemotherapy (group A) or radiotherapy alone (group B). The induction chemotherapy consists of cisplatin (80 mg/m2) day ...
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Locally advanced non-small cell lung cancer (NSCLC) is a heterogeneous disease, and we have embarked on an era where patients will benefit from individualized therapeutic strategies based on identifiable molecular characteristics of the tumor. The landmark studies demonstrating the importance of molecular characterization of tumors for NSCLC patients, the promising molecular pathways, and the p...
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Radiotherapy is a mainstay of treatment of locally advanced Non-Small Cell Lung Cancer (NSCLC). Despite that there is a relative paucity of prospective trials directed on the radiotherapy use in this indication in comparison with prospective studies related to the use of chemotherapy. In this context, a recently published randomized study by [1]. is certainly to be welcomed. This randomized pha...
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Introduction: Chemoradiation is a well-established protocol for management of localized esophageal cancer. However, some early and late toxicities are associated with this therapy. Plan evaluation in term of normal tissue complication probability (NTCP) may help clinicians to tailor this therapy more individually. Given the variety of present radiobiological models, the choice...
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2019
ISSN: 0167-8140
DOI: 10.1016/j.radonc.2019.05.011